Regenerative Medicine Today welcomes Dr. Lance Davidson.  Dr. Davidson is a Professor and Wellington C. Carl Faculty Fellow of Bioengineering in the University of Pittsburgh’s Swanson School of Engineering.   Dr. Davidson discusses his research in the interfaces between engineering, physics, and biology.

For more information about Dr. Davidson, please click here.

Host John Murphy.

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Regenerative Medicine Today welcomes Gary An, MD. Dr. An is an Associate Professor of Surgery at the University of Chicago. Dr. An discusses the application of complex systems analysis to sepsis and inflammation through modeling.

For more information about Dr. An, click here.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:

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Regenerative Medicine Today welcomes Clifford Brubaker, PhD; Yoram Vodovotz, PhD; and Katherine Verdolini Abbott, PhD. Dr. Brubaker is the Dean and Professor of the School of Health and Rehabilitation Science at the University of Pittsburgh and a Professor of Neurological Surgery, Pitt’s School of Medicine, and a Professor in the Clinical and Translational Science Institute; Dr. Vodovotz is the Director of the Center for Inflammation and Regenerative Modeling at the McGowan Institute and a Professor in the Department of Surgery with secondary appointments in the Department of Computational & Systems Biology, the Department of Bioengineering, the Department of Immunology, the Department of Communication Science and Disorders , and the Clinical and Translational Science Institute; and Dr. Verdolini Abbott is a Professor of Communication Science and Disorders and a Professor of Otolaryngology in the School of Health and Rehabilitation Disorders. They discuss their work in inflammation and computational modeling.

For more information about Dr. Verdolini Abbott, click here.

For more information about Dr. Brubaker, please click here.

For more information about Dr. Vodovotz, please click here.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:

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Regenerative Medicine Today welcomes Sam Rothstein.  Mr. Rothstein is a chemical engineering predoctoral fellow in the lab of Dr. Steven Little.  He discusses the lab’s research on the mechanics of controlled release and mathematical model-driven methodology.  He also discusses his plans for a new drug formulation company, ChroKnow Solutions.

For more information about the Little Lab, please click here.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
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Most of us view inflammation in our bodies as something to avoid at all cost.  Severe inflammatory situations such as sepsis, also known as systemic inflammatory response syndrome (SIRS), is a serious medical condition caused by the body’s response to an infection. Sepsis can lead to organ failure, gangrene, and even death.

Clearly inflammation has a bad rap…but some inflammation can be good.  It is essential to the healing process, and it is essential to understand inflammation to predict how drugs (new and proposed) impact healing.

In today’s podcast, Dr. Yoram Vodovotz discusses the research that he and his colleagues are pursuing to model inflammatory responses in the body.  They have used these models to successfully predict the outcomes of drug trials.

While scientists and clinicians can’t know in advance what the outcome of a drug trial is, modeling and simulation can be a great tool to give a preliminary look.  Such simulated clinical trials are attractive, as traditional drug trials are time consuming and may cost $50 -$100 million.  Through modeling, it is possible to rule out which drugs may not work well in advance of the traditional drug trial.  In addition the modeling tools of Dr. Vodovotz and his colleagues can be an asset in rational drug design, helping to define what characteristics the new drug should have.

For more information about Dr. Vodovotz’s work, please click here.

Hosts Leah Kauffman and John Murphy. Interview by Leah Kauffman.

For more information about the McGowan Institute for Regenerative Medicine, visit:

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