RMT Podcast #92 – Prashant Kumta, PhD

Regenerative Medicine Today welcomes Prashant N. Kumta, PhD. Dr. Kumta is the Edward R. Weidlein Chair at the University of Pittsburgh Swanson School of Engineering and is a professor in the Departments of BioEngineering, Chemical and Petroleum Engineering, and Mechanical Engineering and Materials Science. Dr. Kumta discusses his tissue engineering research, focusing on bone regeneration.

For more information about Dr. Kunta, click here.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
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RMT Podcast #83 – Drs. Stephen Badylak and Blair Jobe

Regenerative Medicine Today welcomes Stephen Badylak, DVM, PhD, MD, who is Professor in the Department of Surgery, deputy director of the McGowan Institute for Regenerative Medicine, and Director of the Center for Pre-Clinical Tissue Engineering within the Institute, and Blair Jobe, MD, Associate Professor of surgery in the Heart, Lung and Esophageal Surgery Institute at the University of Pittsburgh and UPMC.  Drs. Badylak and Jobe discuss the recent successful use of tissue engineering in a non-invasive surgery to treat esophageal cancer as well as the potential benefits this technology holds for the future.

For more information about Dr. Badylak, please click here.

For more information about Dr. Jobe, please click here.

To make an appointment with Dr. Jobe, please click here.

To view the CBS 60 Minutes segment that feature Drs. Badylak and Jobe, please click here.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
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RMT Podcast #77 – Thomas Gilbert, PhD

Regenerative Medicine Today welcomes Thomas W. Gilbert, PhD. Dr. Gilbert is an Assistant Professor in the Departments of Surgery and Bioengineering at the University of Pittsburgh.  His research interest are focused on the remodeling of biologic scaffolds for tissue-engineering based treatments, particularly relating to role of mechanical loading in the remodeling process.

He has directed and participated in pre-clinical studies relevant to orthopaedics, cardiac, and gastrointestinal applications.  He discusses his current research programs targeting tracheal reconstruction (with a particular focus on epithelialization and mechanical integrity of the graft) and tissue engineering approaches to pediatric congenital heart defects.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
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RMT Podcast #72 – Bryan Tillman, MD, PhD

Regenerative Medicine Today welcomes Dr. Bryan Tillman.  Dr. Tillman is an assistant professor in the Division of Vascular Surgery at the University of Pittsburgh Medicine Center as well as a practicing clinician.  Dr. Tillman discusses the applications of tissue engineering to construct replacement vessels for patients with peripheral vascular disease.

For more information about the Dr. Tillman, please click here.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
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RMT Podcast #69 – Marie Csete, MD, PhD

Regenerative Medicine Today welcomes Marie Csete, MD, PhD.  Dr. Csete is the Chief Scientific Officer at the California Institute for Regenerative Medicine.  Dr. Csete discusses the origin of the California Institute for Regenerative Medicine as well as what she sees as the future of regenerative medicine and stem cell therapies.

For more information about the California Institute for Regenerative Medicine, please click here.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
McGowan Institute Research Site
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RMT Podcast #55 – Newell Washburn, PhD

Regenerative Medicine Today welcomes Dr. Newell Washburn, who is an Assistant Professor, in the Departments of Chemistry and Biomedical Engineering at Carnegie Mellon University.

Dr. Washburn’s primary research interests include wound healing and bone tissue engineering though the use of biomaterials that can used to form novel polymeric scaffolds for regenerative therapy, transport and interactions of signaling proteins with scaffolds and extracellular matrix. His focus is on creating materials capable of regulating the activities of soluble signaling proteins involved in inflammatory and immune responses. He discusses his current studies, and shares his vision on the application of these emerging technologies for clinical applications.

For more information about the Washburn Lab, please click here.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
McGowan Institute Research Site
McGowan Institute Patient Site
McGowan Institute on Facebook
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RMT Podcast #48 – Joan Schanck

Regenerative Medicine Today welcomes Joan Schanck.  Ms. Schanck is the Director, Education and Workforce Development at the Pittsburgh Tissue Engineering Initiative (PTEI).  PTEI’s educational programs provide a range of experiences and tools for those who are interested in science education.  Beginning with K-12 and continuing through undergraduate and postdoctoral research, PTEI is helping to prepare a trained workforce to support a growing regenerative medicine industry. Through its programs PTEI provides hands-on opportunities to explore the many educational and career paths available to next-generation scientists and those who will work with them.

Ms. Schanck discusses the range of established programs and new initiatives at PTEI that provide opportunities to enhance the understanding and appreciation of the capabilities and opportunities that tissue engineering and regenerative medicine offer.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
McGowan Institute Research Site
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McGowan Institute on Facebook
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RMT Podcast #47 – Phil Campbell, PhD

Regenerative Medicine Today welcomes Dr. Phil G. Campbell.  Dr. Campbell is a Research Professor, Institute of Complex Engineered Systems, Carnegie Mellon University (CMU).  Also he has academic appointments in the Departments of Biomedical Engineering, Biological Sciences, Materials Science and Engineering, and the Molecular Biosensor and Imaging Center at CMU.

Dr. Campbell’s research is focused on the development of “tool sets” that will be resources for regenerative medicine research and clinical therapies.  In the podcast he discusses his work on methodologies and systems that will be required for cell expansion on a commercial vs. a research basis, and how his research is addressing those needs.

He also shares some insight into the use of inkjet printing technologies to print tissue engineered constructs using “bio-inks” vs. the traditional inks used in such printers.  These tool sets are proving to be a significant resource in the study of cell growth on tissue engineered constructs.

Finally, Dr. Campbell discusses his strong commitment to science-based education: from elementary students to senior citizens.

For more information on Dr. Campbell, please click here.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
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RMT Podcast #43 – Jennifer Ogilvie, MD

Regenerative Medicine Today welcomes Jennifer Braemar Ogilvie, MD.  Dr. Ogilvie is an Assistant Professor in the Department of Surgery, Division of Surgical Oncology, Section of Endocrine Surgery at the University of Pittsburgh Medical Center, and a faculty member at the McGowan Institute for Regenerative Medicine.

Dr. Ogilvie discusses her clinical focus on endocrine surgery and her current regenerative medicine research interests that focus on the development of tissue-engineered endocrine organs, in particular bioengineered parathyroid and adrenal glands. Also, her initial studies on the development of a tumor vaccine and her strong commitment to student mentoring are discussed.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
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RMT Podcast #41 – David Vorp, PhD

Dr. David Vorp is an Associate Professor of Surgery and Bioengineering. He is also the Director of the Vascular Surgery and Vascular Biomechanics Research Lab. His research focuses on the assessment of mechanical factors in the genesis and progression of vascular diseases such as arterial aneurysms, atherosclerosis, vascular graft failure, etc., and in the development of tissue-engineered blood vessels. Dr. Vorp also describes some of the new initiatives of his lab such as the use of tissue engineering to treat urethral dysfunction.

On the podcast, Dr. Vorp introduces his innovative approaches to treat vascular disease and shares the status of these emerging technologies. He also shares his insights on Bioengineering education at the University of Pittsburgh.

For more information on Dr. Vorp, please click here.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
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RMT Podcast #42 – SYIS-TERMIS

Regenerative Medicine Today had an opportunity to visit with the leadership of the North American Chapter of the Students and Young Investigators Section of the Tissue Engineering & Regenerative Medicine International Society (SYIS-TERMIS) during the 2007 TERMIS North America Meeting that was held in Toronto in June 2007.

At the time of the meeting, the following SYIS-TERMIS North American Section Officers participated in the discussion:

  • Tiffany Sellaro – Chair (now Past Chair)
  • Alison McGuigan – Treasurer
  • Jolene Valentin – Secretary
  • Masoud Yeganegi – Scientific and Professional Development Committee Chair
  • Doug Baumann – Meeting and Fundraising Committee Chair

For more information on the participants and their responsibilities and areas of study, please click here.

On the podcast, the SYIS-TERMIS-NA leadership reviews the vision and the operations of the Chapter and the benefits of students and post-doctoral fellows joining the Society.

For more information on TERMIS, click here.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:

McGowan Institute Research Site
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RMT Podcast #39 – Kim Jones, PhD

Dr. Kim S. Jones visits Regenerative Medicine Today and gives us an insight into her exciting research in regenerative medicine. Dr. Jones is an Assistant Professor, Department of Chemical Engineering, McMaster University.

Her research interests center on the interactions between tissue engineering and the host response. Tissue engineering is intended to repair, replace or regenerate diseased or damaged tissue.  Typically, tissue-engineered constructs are composed of a biomaterial scaffold and functional cells. Such constructs are intended to supplement the supply of organs for transplant. Examples include vascular grafts, skin, artificial kidneys, livers and hearts. Dr. Jones research uses prototype systems to focus on two fundamental issues.

  • Host Response to Tissue-Engineered Constructs
  • Effect of Host Response on Remodeling in Tissue Engineering

When a body receives an implant, it responds with scarring, inflammation, wound healing or regeneration. It is thus inevitable that tissue-engineered constructs will be remodeled once implanted. Her goal is to divert the remodeling response toward regeneration, but this may be confounded by the nature of the implant. Many of the mediators and cells involved in immune and inflammatory responses are also involved in wound healing and regeneration. As such, we expect that methods used to minimize damaging responses will interact with regeneration. Understanding this interaction is critical in order to direct intelligent design for the next generation of tissue engineering.  On the podcast, Dr. Jones describes her work and shares her vision for the future.

Details of Dr. Jones’ work are available here.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
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RMT Podcast #38 – Anshu Mathur, PhD

Dr. Anshu Mathur visits Regenerative Medicine Today and introduces us to her exciting research on regenerative medicine. Dr. Mathur is an Assistant Director for Research at the Laboratory of Reparative Biology and Bioengineering at M. D. Anderson Cancer Center.

Dr. Mathur’s research objective focuses on elucidating the cell-cell and cell-matrix interactions in tissue engineered constructs developed from biologically derived materials for the treatment of chronic dermal wounds, where mechanical coupling of cell-matrix interface leads to contraction of the wound and cell-cell coupling is required to vascularize and activate normal scarring.

Her current projects are addressing the following areas:

  • To elucidate the therapeutic effects of chitosan-fibroin biopolymer blends on matrix-remodeling in order to transform the mechanical environment of the wound, redistribute cell focal adhesions, and influence mechanical properties of the cell and the matrix.
  • To exploit silk fibroin biopolymer micro/nano structure to tissue-engineer a scaffold that supports angiogenesis in order to provide blood supply to a healing wound.
  • To assess the synergistic effects of emodin loaded chitosan-fibroin nanospheres on chronic dermal wounds and scars by examining the RTK signaling to matrix adhesion sites in fibroblasts using TIRFM, thus providing a novel way to study therapeutic effects of drugs.

Additionally, Dr. Mathur describes a new academic program in bioengineering that is under development at the M.D. Anderson/University of Texas at Austin.

Details of Dr. Mathur’s work are available here.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
McGowan Institute Research Site
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RMT Podcast #36 – Alejandro Nieponice, MD, PhD

Alejandro Nieponice, MD, PhD visits regenerative medicine today and discusses his studies related to tissue engineering and translational medicine. Dr. Alejandro Nieponice is currently a Research Assistant Professor of the department of surgery at University of Pittsburgh and faculty of the McGowan Institute for Regenerative Medicine. He is also a surgical associate and director of the Clinical Translation Unit at the Austral University Hospital in Buenos Aires, Argentina.

Dr. Nieponice’s main goal is to foster clinical translation of novel tissue engineering approaches by bridging his surgical and research backgrounds. To accomplish that, he has promoted the creation of a Clinical Translation Unit within the operative room at the Austral University Hospital, providing full cell culture capabilities to facilitate clinical translation of cell-based technologies.

Details of Dr. Nieponice’s work are available here.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
McGowan Institute Research Site
McGowan Institute Patient Site
McGowan Institute on Facebook
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RMT Podcast #35 – Milica Radisic, PhD

Dr. Milica Radisic visits Regenerative Medicine Today and discusses her studies related to functional tissue engineering. Dr. Radisic is an Assistant Professor, Institute of Biomaterials and Biomedical Engineering, Department of Chemical Engineering and Applied Chemistry, University of Toronto.

In the podcast, Dr. Radisic discusses the research in the Laboratory for Functional Tissue Engineering at the University of Toronto; focus areas include:

  • Biomimetic approach to cardiac tissue engineering
  • Development of functional, clinically sized (1-5 mm thick), compact cardiac constructs with physiologically relevant cell densities (108 cells/cm3)
  • Advanced bioreactors for functional tissue engineering of myocardium
  • Biophysical modulation of engineered myocardium
  • Separation of heterogeneous cell populations (MEMS)

For more information on Dr. Radisic, please click here.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
McGowan Institute Research Site
McGowan Institute Patient Site
McGowan Institute on Facebook
McGowan Institute on Twitter

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