George Christ, PhD visits Regenerative Medicine Today and shares his vision on regenerative medicine. Dr. Christ is a professor at Wake Forest University and the Wake Forest Institute for Regenerative Medicine.

Dr. Christ’s research interests are in the area of functional genomics, that is, establishing a verifiable link between changes in gene expression and alterations in cell/organ/tissue function/dysfunction, and then using this information to improve the understanding, diagnosis and treatment of smooth muscle diseases/disorders. To this end, Dr. Christ has developed a multidisciplinary approach that utilizes various visceral and vascular smooth muscle tissues/organs to attempt to establish “cause and effect” relationships between molecular/genetic alterations and measurable changes in organ function, namely, contraction and relaxation of smooth muscle cells.

Details of Dr. Christ’s work are available here.

To learn more about the Wake Forest Institute for Regenerative Medicine, please click here.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
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Dr. Bruno Peault visits Regenerative Medicine Today and discusses the status of his emerging results on the identification, characterization and application of adult stem cells for therapeutic applications.

Dr. Bruno Peault and his colleague, Dr. Johnny Huard, provide the leadership for the Stem Cell Research Center at the University of Pittsburgh/Children’s Hospital of Pittsburgh. The Center focuses on expanding the possibilities of tissue engineering by unlocking the potential of gene therapy and adult stem cell research and transferring research findings into the development of effective treatments for damaged or diseased tissues.

In this podcast, Dr. Peault highlights some of the promising initiatives emerging from his laboratories and explores the future in cell-based therapies. One of the topics addressed in the interview is that the Peault Lab has identified that adult human adipose tissue is an accessible source of perivascular cells. These cells exhibit multilineage potential; these results suggest that the adipose tissue-derived pericyte is an attractive candidate for cell-based therapy of muscle diseases, and also indicates the likely vascular origin of the elusive fat-derived stem cells.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
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In Podcast 30, we meet Ajit Yoganathan, PhD, Regents’ Professor, Associate Chair for Research, and the Wallace H. Coulter Distinguished Faculty Chair in Biomedical Engineering at Georgia Institute of Technology.

Dr. Yoganathan and his colleagues are focusing on the development artificial heart valves and the use of novel instrumentation such as Doppler ultrasound and magnetic resonance imaging to non-invasively study blood flow patterns in the heart.

Dr. Yoganathan established and leads the Cardiovascular Fluid Mechanics Laboratory at Georgia Institute of Technology. The objective of this laboratory is to integrate biological knowledge with engineering principles to understand the function and mechanics of various cardiovascular diseases and help the cardiac surgeons in planning, developing and implementing novel surgical repair techniques using state-of-the-art technology available today. The key thrust areas of the laboratory are in understanding the function and mechanics of native and prosthetic heart valves and in correcting pediatric and adult congenital heart defects.

Host John Murphy.

For more information about the McGowan Institute for Regenerative Medicine, visit:
McGowan Institute Research Site
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In Podcast 27, we meet Dr. Michael Chancellor who is a Professor of Urology at the University of Pittsburgh as well as a practicing OBGYN. Within the School of Medicine, he is also the Director of Neurourology and Urinary Incontinence Programs. In addition, Dr. Chancellor is the Director of the Mentored Clinical Scientist Development Program in Urology, a research training program sponsored by the National Institute of Health (NIH).

Dr. Chancellor’s research interests include developing a new and novel solution to an age-old problem…urinary incontinence. This is a problem that affects over 17 million in the United States. The adult diaper market is estimated to be a $4 billion dollar a year business!

Clinically, Dr. Chancellor uses all of the available resources to treat urinary incontinence, ranging from exercise, to medication, to injection of collagen, to surgery. The injection of collagen can be effective…but for only short periods.

In collaboration with Dr. Johnny Huard, they have developed a promising alterative approach to the treatment of adult urinary incontinence…the use of the patient’s own stem cells that are harvested from the patient’s leg muscle. This technology has been licensed and Cook Myosite.

This novel procedure has been recently tested for safety in humans, and as a result of the positive results, an expanded clinical trial will begin soon to further investigate the effectiveness of this therapy.

Hosts Leah Kauffman and John Murphy. Interview by Leah Kauffman.

For more information about the McGowan Institute for Regenerative Medicine, visit:

McGowan Institute Research Site
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When the spinal cord is injured, commands and sensations can’t travel between the limbs and the brain, so arms and legs are can’t respond to the will to move. Until recently, physicians have not been able to offer spinal cord injury patients much hope for regaining function.

But if the brain’s intention could be communicated to muscles by detouring around the damaged spinal cord, movement might be restored. As you’ll hear in podcast #10, that’s just what Dr. Patrick Crago is doing with small, implantable electrodes to stimulate muscles to contract, thereby restoring some function to hands and arms. Working with what they call “neural prostheses,” Dr. Crago and his team are developing ways to make the stimulated muscles act in a coordinated way so that people with spinal cord injuries can grasp objects and, in the second generation neural prosthesis, reach for things overhead.

About 200 patients have benefited from a first generation system that provided hand grasp function. Dr. Crago and his colleagues are now working on a system that provides function to the wrist and elbow; over 40 patients around the world are using this latest upper extremity neural prostheses.

Patrick E. Crago, PhD, is the Allen H. and Constance T. Ford Professor and chairman of the Department of Biomedical Engineering at Case Western Reserve University. For more information about his research, visit Dr. Crago’s web site. [http://bme.case.edu/faculty_staff/crago/]

To learn more about the work of Dr. Crago and his colleagues, please see the Cleveland Functional Electrical Stimulation Center web site. To inquire about participating in a clinical trial, Dr. Crago suggests that you contact the center.

Hosts Leah Kauffman and John Murphy. Interview by Leah Kauffman.

For more information about the McGowan Institute for Regenerative Medicine, visit:

McGowan Institute Research Site
McGowan Institute Patient Site
McGowan Institute on Facebook

Modern knee and hip replacement procedures rely on a number of advanced materials, as well as the effectiveness of the bond between the joint appliance and the patient’s bone that the artificial joint must bond with.

In podcast #6, we’ll hear from Dr. Andrés García. Dr. Garcia’s research centers on cellular and tissue engineering and his research addresses areas which integrate engineering and biological principles to restore and enhance function to injured or diseased organs. Specifically, his research focuses on fundamental structure-function relationships that govern cell-biomaterials interactions for bone and muscle applications.

In another project, the Garcia lab is developing surfaces that are engineered to control the distribution and biological activity of extracellular matrix proteins in order to elicit specific and directed cellular responses. For instance, fibronectin adsorption onto different surfaces results in conformational changes which lead to differences in cell receptor binding and signaling and modulate switching between muscle cell proliferation and differentiation. This principle can then be applied to the development of synthetic and natural scaffolds for enhanced tissue reconstruction and regeneration. For more information, please visit Dr. Garcia’s web site.

Leah Kauffman also visits with Tiffany Sellaro and learns about TERMIS-SYIS, a student group that aims to serve as a common platform to generate interest and promote interaction among undergraduate and graduate students, post-doctoral researchers and young investigators in industry and academia related to tissue engineering and regenerative medicine. TERMIS-SYIS will closely follow the organizational and the working pattern of TERMIS and will be formally launched in April 2006 at the Regenerate World Congress in Pittsburgh (April 2006).

Hosts Leah Kauffman and John Murphy. Interview by Leah Kauffman.

For more information about the McGowan Institute for Regenerative Medicine, visit:
McGowan Institute Research Site
McGowan Institute Patient Site
McGowan Institute on Facebook

A impaired heart can doom a person to a shortened life span of limited mobility, each movement a tremendous effort. More than 13 million Americans suffer from heart disease. Each year, 500,000 Americans are diagnosed with heart failure, the most severe form of heart disease. Heart disease can be treated with medications and surgery, but transplantation is the nearest to a cure traditional medicine can offer … for now.

But it won’t be long before heart disease is treated with a minimally-invasive procedure with no serious side effects: an injection of stem cells from the patient’s own bone marrow or blood. Such treatments are already available overseas and are in clinical trials in the United States.

In podcast #5, we’ll hear from Dr. Amit Patel. He was one of the first physician-scientists to use adult stem cells to treat heart failure, and his group continues to research and refine their use.

At the time of recording, Amit N. Patel, MD, MS, was the director of the Center for Cardiac Cell Therapy at the University of Pittsburgh Medical Center, and at the McGowan Institute for Regenerative Medicine. For more information about Dr. Patel’s current work, click here.

Hosts Leah Kauffman and A.J. Malkiewicz. Interview by Leah Kauffman.

For more information about the McGowan Institute for Regenerative Medicine, visit:

McGowan Institute Research Site
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Our heart pumps about 2,000 gallons of blood each day. Our heart valves ensure all that blood moves in the right direction. When a heart valve fails, the heart must work harder to keep organs properly nourished. If the heart works too hard, it can begin to weaken and fail.

Malfunctioning heart valves can be replaced with animal or synthetic valves, but these have limited life spans. In podcast #4, Dr. Frederick Schoen describes how regenerative medicine researchers are laying the foundation for working heart valves made of natural materials that won’t wear out before we do, and that can even grow along with the young patients they might help. Dr. Schoen’s own work in developmental biology, examining how an embryo successfully “engineers” a heart valve as it grows, is an important part of this effort.

Frederick J. Schoen, MD, PhD, is a professor of pathology and health sciences and technology at Harvard Medical School and Brigham & Women’s Hospital.

For more information about Dr. Schoen’s work, see his click here.

For more information about the McGowan Institute for Regenerative Medicine, visit:

McGowan Institute Research Site
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Regenerative Medicine Today welcomes Dr. Alyssa Panitch, who is an Assistant Professor in the Harrington Department of Bioengineering at Arizona State University. In this podcast she discusses her research into methods to improve regeneration of the central nervous system.

Hosts: John Murphy and Leah Kauffman

For more information about the McGowan Institute for Regenerative Medicine, visit:

McGowan Institute Research Site
McGowan Institute Patient Site
McGowan Institute on Facebook